Ethanol → Ethyl 2-[4-(4-chlorophenyl)benzyloxy]-2-phenylacetate

HRID 1105873Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1105873
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:25]=[CH:24][C:11]([CH2:12][O:13][CH:14]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:15]([OH:17])=[O:16])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.S(=O)(=O)(O)O.C(=O)(O)[O-].[CH2:35](O)[CH3:36]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:25]=[CH:24][C:11]([CH2:12][O:13][CH:14]([C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)[C:15]([O:17][CH2:35][CH3:36])=[O:16])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

Komponenten

5

Edukt 4

HCID 702EthanolHCID 769Bicarbonate IonHCID 1118Sulfuric AcidHCID 98633512-[4-(4-Chlorophenyl)benzyloxy]-2-phenylacetic acid

Produkt 1

HCID 20555293Ethyl 2-[4-(4-chlorophenyl)benzyloxy]-2-phenylacetate

Versuchsvorschrift

A solution of 2-[4-(4-chlorophenyl)benzyloxy]-2-phenylacetic acid (8.0 g.) in ethanol (200 ml.) containing concentrated sulphuric acid (1 ml.) was heated under reflux for 90 minutes, then cooled to room temperature, and carefully neutralised by addition of an excess of saturated aqueous bicarbonate solution. The mixture obtained was evaporated and the residue extracted thoroughly with ethyl acetate. The combined extracts were washed with water, dried (MgSO4) and evaporated to give ethyl 2-[4-(4-chlorophenyl)benzyloxy]-2-phenylacetate (6.65 g.), m.p. 50°-51° C.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 90 minutes
  3. customThe mixture obtained
  4. customwas evaporated
  5. extractionthe residue extracted thoroughly with ethyl acetate
  6. washThe combined extracts were washed with water
  7. dry with materialdried (MgSO4)
  8. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-849d0e41554c4a528911e78e602a55cf
Quelldatensatz
uspto-grants-1982_01
Patentnummer
US04310544

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