Ammonia → (8S)-7-(3-mercapto-2-methylthio-1-oxopropyl)-1,4-dioxo-7-azaspiro[4.4]nonane-8-carboxylic acid
Reaktionsgleichung
C([S:4][CH2:5][CH:6]([S:23][CH3:24])[C:7]([N:9]1[C@H:19]([C:20]([OH:22])=[O:21])[CH2:18][C:11]2([C:15](=[O:16])[CH2:14][CH2:13][C:12]2=[O:17])[CH2:10]1)=[O:8])(=O)C.N>>[SH:4][CH2:5][CH:6]([S:23][CH3:24])[C:7]([N:9]1[C@H:19]([C:20]([OH:22])=[O:21])[CH2:18][C:11]2([C:15](=[O:16])[CH2:14][CH2:13][C:12]2=[O:17])[CH2:10]1)=[O:8]Komponenten
3
Versuchsvorschrift
The product from part (c) is treated with concentrated ammonia according to the procedure of Example 2 to yield (8S)-7-(3-mercapto-2-methylthio-1-oxopropyl)-1,4-dioxo-7-azaspiro[4.4]nonane-8-carboxylic acid.
Quellen und Nachweise
- ORD-Eintrag
- ord-3b397fe47e5f420eb7f734036e2217ea
- Quelldatensatz
- uspto-grants-1982_01
- DOI