Dimethylamine → 2-bromo-N,N-dimethylbenzylamine

HRID 1107724

Reaktionsgleichung

Reaktionsgleichung von HRID 1107724
[CH3:1][NH:2][CH3:3].[Br:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH2:7]Br>CO>[Br:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH2:7][N:2]([CH3:3])[CH3:1]

Komponenten

4

Edukt 2

HCID 674DimethylamineHCID 769652-Bromobenzyl bromide

Produkt 1

HCID 747922-bromo-N,N-dimethylbenzylamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Dimethylamine (33% w/w in methanol) (25 ml) was added to 2-bromobenzylbromide (7.5 g 30 mmol) at 0° C. in methanol (35 ml), and the solution stirred for 30 min., evaporated, diluted with water and extracted twice with diethyl ether. The combined extracts were dried over sodium sulphate and evaporated to give product as a yellow oil (6.0 g). M+ 215/213; 360 MHz 1H n.m.r (CDCl3) 7.54 (1H, dd, J 1.2, 8.0 Hz), 7.42 (1H, dd, J 1.6, 7.6 Hz), 7.30-7.26 (1H, m), 7.11 (1H, dt, J 1.7, 7.7 Hz), 3.52 (2H, s), 2.30 (6H, s).

Aufarbeitung

  1. customevaporated
  2. additiondiluted with water
  3. extractionextracted twice with diethyl ether
  4. dry with materialThe combined extracts were dried over sodium sulphate
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-df42aafd75f442d2b8d83ab3dd190459
Quelldatensatz
uspto-grants-2000_05
Patentnummer
US06063789

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