Methyl 4-(3-mercaptophenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate → Ethyl 4-[3-[4-(2-methylimidazol-1-yl)phenylthio]phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate

HRID 1108077

Reaktionsgleichung

Reaktionsgleichung von HRID 1108077
[SH:1][C:2]1[CH:3]=[C:4]([C:8]2([C:14]([O:16][CH3:17])=[O:15])[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1.[CH3:18][C:19]1[N:20]([C:24]2[CH:29]=[CH:28][C:27](I)=[CH:26][CH:25]=2)[CH:21]=[CH:22][N:23]=1.[CH3:31]C(C)([O-])C.[Na+]>C(O)C.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH3:18][C:19]1[N:20]([C:24]2[CH:29]=[CH:28][C:27]([S:1][C:2]3[CH:3]=[C:4]([C:8]4([C:14]([O:16][CH2:17][CH3:31])=[O:15])[CH2:13][CH2:12][O:11][CH2:10][CH2:9]4)[CH:5]=[CH:6][CH:7]=3)=[CH:26][CH:25]=2)[CH:21]=[CH:22][N:23]=1

Komponenten

6

Edukt 3

HCID 11242202Methyl 4-(3-mercaptophenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxylateHCID 112890901-(4-iodophenyl)-2-methyl-1H-imidazoleHCID 23676156Sodium t-butoxide

Produkt 1

HCID 11154431Ethyl 4-[3-[4-(2-methylimidazol-1-yl)phenylthio]phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carboxylateAusbeute 60,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418397HCID 178418397, VerbindungKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of methyl 4-(3-mercaptophenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate (1.04 g, 3.5 mmol), 4-(2-methylimidazol-1-yl)phenyliodide (0.89 g, 3.5 mmol), sodium t-butoxide (673 mg, 7 mmol) and tetrakis(triphenylphosphine)palladium (162 mg, 0.14 mmol) in dry ethanol (20 ml) was heated to reflux with stirring overnight. Volatiles were remeved by evaporation and the residue was partitioned between ethyl acetate (100 ml) and water (100 ml). The aqueous layer was extracted with ethyl acetate (100 ml). The combined organic layers were washed with brine (100 ml), dried (magnesium sulfat) and concentrated to dryness to give 1.09 g of crude product as a brown liquid. Purification by column chromatography (silica-gel, 50 g; methanol in dichloromethane, increasing the ratio of methanol from 0% to 4%) afforded the titled compound (0.90 g).

Aufarbeitung

  1. temperatureto reflux
  2. customVolatiles were remeved by evaporation
  3. customthe residue was partitioned between ethyl acetate (100 ml) and water (100 ml)
  4. extractionThe aqueous layer was extracted with ethyl acetate (100 ml)
  5. washThe combined organic layers were washed with brine (100 ml)
  6. dry with materialdried (magnesium sulfat)
  7. concentrationconcentrated to dryness
  8. customto give 1.09 g of crude product as a brown liquid
  9. customPurification by column chromatography (silica-gel, 50 g
  10. temperaturemethanol in dichloromethane, increasing the ratio of methanol from 0% to 4%)

Quellen und Nachweise

ORD-Eintrag
ord-c8111a64e6d54f2191828c98f2bea4d2
Quelldatensatz
uspto-grants-2000_05
Patentnummer
US06063928

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