4-cyano-4-(3-triisopropylsilylthiophenyl)-3,4,5,6-tetrahydro-2H-pyran → 4-Cyano-4-[3-[4-(1,2,4-triazol-4-yl)phenyl]thiophenyl]-3,4,5,6-tetrahydro-2H-pyran

HRID 1108107Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1108107
[C:1]([C:3]1([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([S:16][C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH:27]=C[N:25]=[C:24]4C)=[CH:19][CH:18]=3)[CH:11]=2)[CH2:8][CH2:7][O:6][CH:5](C)[CH2:4]1)#[N:2].[NH:29]1C=C(C2C=CC(I)=CC=2)N=N1.C(C1(C2C=CC=C(S[Si](C(C)C)(C(C)C)C(C)C)C=2)CCOCC1)#N.C(C1(C2C=CC=C(S[Si](C(C)C)(C(C)C)C(C)C)C=2)CCOC(C)C1)#N>>[C:1]([C:3]1([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([S:16][C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH:24]=[N:25][N:29]=[CH:27]4)=[CH:19][CH:18]=3)[CH:11]=2)[CH2:4][CH2:5][O:6][CH2:7][CH2:8]1)#[N:2]

Komponenten

5

Edukt 4

HCID 113608724-cyano-4-(3-triisopropylsilylthiophenyl)-3,4,5,6-tetrahydro-2H-pyranHCID 18786333(2SR,4RS)-4-cyano-2-methyl-4-(3-triisopropylsilylthiophenyl)-3,4,5,6-tetrahydro-2H-pyranHCID 18786347(2SR,4RS)-4-cyano-2-methyl-4-[3-[4-(2-methylimidazol-1-yl) phenylthio]phenyl]-3,4,5,6-tetrahydro-2H-pyranHCID 178506541HCID 178506541, Verbindung

Produkt 1

HCID 540996204-Cyano-4-[3-[4-(1,2,4-triazol-4-yl)phenyl]thiophenyl]-3,4,5,6-tetrahydro-2H-pyran

Versuchsvorschrift

The titled compound was prepared according to the procedure described in example 29E for the preparation of (2SR,4RS)-4-cyano-2-methyl-4-[3-[4-(2-methylimidazol-1-yl)phenylthio]phenyl]-3,4,5,6-tetrahydro-2H-pyran using 4-(triazol-4-yl)phenyl iodide and 4-cyano-4-(3-triisopropylsilylthiophenyl)-3,4,5,6-tetrahydro-2H-pyran in place of 4-(2-methylimidazol-1-yl)phenyl iodide and (2SR,4RS)-4-cyano-2-methyl-4-(3-triisopropylsilylthiophenyl)-3,4,5,6-tetrahydro-2H-pyran, respectively. MS(EI): m/z 362(M+)

Quellen und Nachweise

ORD-Eintrag
ord-daa165e0cdf74630abc07861e6d5b21b
Quelldatensatz
uspto-grants-2000_05
Patentnummer
US06063928

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