Trifluoroacetic acid → 4-(4-Bromo-7-methoxybenzofuran-2-ylmethoxy)-piperidine

HRID 1108320Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1108320
FC(F)(F)C(O)=O.C(OC([N:15]1[CH2:20][CH2:19][CH:18]([O:21][CH2:22][C:23]2[O:24][C:25]3[C:31]([O:32][CH3:33])=[CH:30][CH:29]=[C:28]([Br:34])[C:26]=3[CH:27]=2)[CH2:17][CH2:16]1)=O)(C)(C)C>ClCCl>[Br:34][C:28]1[C:26]2[CH:27]=[C:23]([CH2:22][O:21][CH:18]3[CH2:19][CH2:20][NH:15][CH2:16][CH2:17]3)[O:24][C:25]=2[C:31]([O:32][CH3:33])=[CH:30][CH:29]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 540770204-(4-Bromo-7-methoxybenzofuran-2-ylmethoxy)-piperidine-1-carboxylic Acid tert-butyl Ester

Produkt 1

HCID 187848694-(4-Bromo-7-methoxybenzofuran-2-ylmethoxy)-piperidineAusbeute 97,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

Trifluoroacetic acid (5 ml) was added to a stirred solution of 4-(4-bromo-7-methoxybenzofuran-2-ylmethoxy)-piperidine-1-carboxylic acid tert-butyl ester (1.3 g) in dichloromethane (50 ml). After stirring at room temperate overnight the reaction was diluted with dichloromethane (150 ml) washed with 1M sodium hydroxide (100 ml) and dried over magnesium sulfate. The organic phase was concentrated in vacuo to afford the title compound as a pale yellow gum (0.98 g).

Aufarbeitung

  1. washwashed with 1M sodium hydroxide (100 ml)
  2. dry with materialdried over magnesium sulfate
  3. concentrationThe organic phase was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-ce50eecc609e43c3b6455bd48d38dc13
Quelldatensatz
uspto-grants-2000_05
Patentnummer
US06066657

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