Hydrochloric Acid → HCID 18785143, Verbindung

HRID 1108496Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1108496
C(OC([N:8]1[C:12]2[C:13]([F:19])=[CH:14][C:15]([NH2:18])=[C:16]([CH3:17])[C:11]=2[N:10]=[CH:9]1)=O)(C)(C)C.[ClH:20]>>[ClH:20].[CH3:17][C:16]1[C:11]2[NH:10][CH:9]=[N:8][C:12]=2[C:13]([F:19])=[CH:14][C:15]=1[NH2:18]

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 18785142HCID 18785142, Verbindung

Produkt 1

HCID 18785143HCID 18785143, Verbindung

Versuchsvorschrift

1-tert-Butoxycarbonyl-4-methyl-5-amino-7-fluorobenzimidazole (1 g) (prepared as described in U.S. Pat. No. 5,478,858 issued to Cupps and Bogdan, Dec. 26, 1995, incorporated herein by reference) and 6N HCl (10 mL) are combined and heated to reflux while stirring. After completion of the t-BOC group deprotection, the reaction mixture is concentrated under reduced pressure and dried to furnish 4methyl-5-amino-7-fluorobenzimidazole hydrochloride.

Aufarbeitung

  1. temperatureheated
  2. temperatureto reflux
  3. concentrationAfter completion of the t-BOC group deprotection, the reaction mixture is concentrated under reduced pressure
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-25207606004a45c7b45f8040b0f4e281
Quelldatensatz
uspto-grants-2000_05
Patentnummer
US06066740

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