Hydrochloric Acid → 5-(3,4-Dimethoxyphenyl)cyclohexane-1,3-dione

HRID 1108754Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1108754
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]2[CH2:16][C:15](=[O:17])[CH2:14][C:13](=[O:18])[CH:12]2C(OCC)=O)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].Cl>[OH-].[K+]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]2[CH2:16][C:15](=[O:17])[CH2:14][C:13](=[O:18])[CH2:12]2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 18784169HCID 18784169, Verbindung

Produkt 1

HCID 8541355-(3,4-Dimethoxyphenyl)cyclohexane-1,3-dioneAusbeute 90,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 14797Potassium HydroxideLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

10% Aqueous solution of potassium hydroxide (760 ml) was added to ethyl 2-(3,4-dimethoxyphenyl)-4,6-dioxocyclohexane carboxylate (122 g), and the mixture was refluxed for 3.5 hours. After cooling the reaction solution on ice, it was adjusted to pH1 with concentrated hydrochloric acid, and stirred at 50° C. for an hour. After allowing the reaction solution to cool, the deposited crystals were filtered by suction and washed with purified water and isopropyl ether to give 85.8 g of 5-(3,4-dimethoxyphenyl)cyclohexane-1,3-dione (90.5%).

Aufarbeitung

  1. temperaturethe mixture was refluxed for 3.5 hours
  2. temperatureAfter cooling the reaction solution on ice, it
  3. temperatureto cool
  4. filtrationthe deposited crystals were filtered by suction
  5. washwashed with purified water and isopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-6b7deb2b253a4881818a6a1f4c9b9727
Quelldatensatz
uspto-grants-2000_05
Patentnummer
US06069176

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