N-(2-Mercaptoethyl)-N'-methyl-2-nitro-1,1-ethenediamine → HCID 178482393, Verbindung

HRID 1108848

Reaktionsgleichung

Reaktionsgleichung von HRID 1108848
[CH3:1][NH:2]/[C:3](/[NH:8][CH2:9][CH2:10][S:11]CC1N=C(CN(C)C)SC=1)=[CH:4]\[N+:5]([O-])=[O:6].ClCC1N=C(CN(C)C)SC=1.SCCNC(NC)=C[N+]([O-])=O>>[CH3:1][NH:2][C:3]1[C:4](=[N:5][OH:6])[S:11][CH2:10][CH2:9][N:8]=1

Komponenten

4

Edukt 3

HCID 181798N-(2-Mercaptoethyl)-N'-methyl-2-nitro-1,1-ethenediamine2×HCID 1967272N-{[4-(chloromethyl)-1,3-thiazol-2-yl]methyl}-N,N-dimethylamineHCID 303363776963-41-2

Produkt 1

HCID 178482393HCID 178482393, Verbindung

Versuchsvorschrift

The preparation of nizatidine by fusing 4-chloromethyl-2-dimethylaminomethylthiazole with N-(2-mercaptoethyl)-N'-methyl-2-nitro-1,1-ethenediamine has been suggested generically in EP 49618. However, we have found that N-(2-mercaptoethyl)-N'-methyl-2-nitro-1,1-ethenediamine cannot be isolated and stored. Our attempts to prepare this compound have always produced the disulphide, N-methyl-[N'-[2-(N"-methyl-2-nitro-1,1-ethenediamine)ethyldisulphanyl]ethyl]-2-nitro-1,1-ethenediamine and 3-methylamino-5,6-dihydro-[1,4]-thiazin-2-one oxime.

Aufarbeitung

  1. customcannot be isolated
  2. customOur attempts to prepare this compound

Quellen und Nachweise

ORD-Eintrag
ord-d4c2628f636343c0950d985ab13926c3
Quelldatensatz
uspto-grants-2000_05
Patentnummer
US06069256

Verknüpfte Notizen

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