HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1109031Erstellt: 25. Oktober 2026
Sulfuric Acid → N5-benzyloxycarbonyl-ornithine, t-butyl ester
https://huagongshe.com/reaction/1109031
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Sulfuric Acid | HCID 1118 | — |
| Edukt | p-Toluenesulfonic acid | HCID 6101 | — |
| Edukt | Sodium Bicarbonate | HCID 516892 | — |
| Edukt | H-Orn(Z)-OH | HCID 7009570 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Lösungsmittel | tert-Butyl acetate | HCID 10908 | — |
| Produkt | N5-benzyloxycarbonyl-ornithine, t-butyl ester | HCID 7019766 | — |
Reaktionsschritte
Suspend N5 -benzyloxycarbonyl-ornithine (80 g, 0.3 mol) in t-butyl acetate (250 mL) and cool to 10° C. Add p-toluenesulfonic acid (57 g, 0.3 mol) and add, by dropwise addition, concentrated sulfuric acid (80 mL). Stir at 10° C. until the reaction is complete, basify to pH 8 by adding a suspension of sodium bicarbonate in water. Extract with ethyl acetate, dry (MgSO4), and evaporate to give N5 -benzyloxycarbonyl-ornithine, t-butyl ester.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US05318992 |
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| Quelldatensatz | uspto-grants-1994_06 |
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| ORD ID | ord-45555e6d55c24eb3af47a6ec852f723c |
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| Quellennotiz | uspto-grants-1994_06 |
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