Hydrochloric Acid → N-propyl-10-[1-(1-pyrroli-dinyl)-2-propyl]-2-phenothiazinecarboxamide hydrochloride
Reaktionsgleichung
[ClH:1].[CH2:2]([NH:5][C:6]([C:8]1[CH:21]=[CH:20][C:19]2[S:18][C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]([CH:22]([CH3:29])[CH2:23][N:24]3[CH2:28][CH2:27][CH2:26][CH2:25]3)[C:10]=2[CH:9]=1)=[O:7])[CH2:3][CH3:4]>C(OC(C)C)(C)C.C(OCC)(=O)C>[ClH:1].[CH2:2]([NH:5][C:6]([C:8]1[CH:21]=[CH:20][C:19]2[S:18][C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]([CH:22]([CH3:29])[CH2:23][N:24]3[CH2:28][CH2:27][CH2:26][CH2:25]3)[C:10]=2[CH:9]=1)=[O:7])[CH2:3][CH3:4]Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Reaktionsbedingungen
- Temperatur
- 5 °C
Versuchsvorschrift
A 3.3N solution (6.2 cc) of hydrochloric acid in isopropyl ether is added dropwise in the course of 5 minutes to a solution of N-propyl-10-[1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide, L series (7.2 g), in anhydrous ethyl acetate (80 cc). The product deposits on the walls and crystallizes on scratching. The suspension obtained is maintained for one hour at a temperature in the region of 5° C. The solid is drained, washed with anhydrous ethyl acetate (3×5 cc) and dried under reduced pressure (5 mm Hg; 0.7 kPa) at 40° C. to give N-propyl-10-[1-(1-pyrroli-dinyl)-2-propyl]-2-phenothiazinecarboxamide hydrochloride, L series (7.1 g), in the form of a white solid, m.p. 190° C.
Aufarbeitung
- customThe product deposits on the walls and crystallizes
- customThe suspension obtained
- washwashed with anhydrous ethyl acetate (3×5 cc)
- customdried under reduced pressure (5 mm Hg; 0.7 kPa) at 40° C.
Quellen und Nachweise
- ORD-Eintrag
- ord-c8fc27434a5f462ab7877d4e60ab109e
- Quelldatensatz
- uspto-grants-1994_06
- Patentnummer
- US05321026
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