5-methoxy-3,4-dihydro-2H-1-benzopyran-3-one → Chromanone

HRID 1109794Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1109794
CO[C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH2:5][C:6](=O)[CH2:7][O:8]2.Cl.NCCCCN1C(=[O:30])CC2(CCCC2)CC1=O>C(O)C>[CH:12]1[CH:11]=[CH:10][C:9]2[O:8][CH2:7][CH2:6][C:5](=[O:30])[C:4]=2[CH:3]=1

Komponenten

4

Edukt 2

HCID 117690965-methoxy-3,4-dihydro-2H-1-benzopyran-3-oneHCID 19019753N-(4-aminobutyl)-8-azaspiro[4.5]decane 7,9-dione hydrochloride

Produkt 1

HCID 68110Chromanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Versuchsvorschrift

0.04 mole of 5-methoxychroman-3-one is dissolved in 10 ml of ethanol. At the same time, 1 g of N-(4-aminobutyl)-8-azaspiro[4.5]decane 7,9-dione hydrochloride is dissolved in 10 ml of ethanol, and the solution of chromanone obtained above is added to this solution. 0.16 g of sodium hydroxide in solution in 10 ml of ethanol is then added thereto. The mixture is stirred for one hour at ambient temperature, filtered and placed in a hydrogenating apparatus. 0.5 g of palladized carbon is added, the apparatus is purged with nitrogen and then with hydrogen, and the mixture is hydrogenated at ambient temperature and pressure. The mixture is filtered and the filtrate is evaporated to dryness. The residue is taken up in ethyl acetate and gaseous hydrochloric acid is added thereto. The mixture is allowed to precipitate and is drained.

Quellen und Nachweise

ORD-Eintrag
ord-19d62cb517384490ae1a85b772704eca
Quelldatensatz
uspto-grants-1994_06
Patentnummer
US05322944

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