Dodecanoyl chloride → HCID 15037050, Verbindung

HRID 1109864Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1109864
[C:1](Cl)(=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[NH2:15][CH2:16][C:17]1[CH:18]=[C:19]([Si:22]([CH2:27][CH3:28])([CH2:25][CH3:26])[CH2:23][CH3:24])[O:20][CH:21]=1.C(N(CC)CC)C>O1CCCC1>[C:1]([NH:15][CH2:16][C:17]1[CH:18]=[C:19]([Si:22]([CH2:25][CH3:26])([CH2:27][CH3:28])[CH2:23][CH3:24])[O:20][CH:21]=1)(=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

Komponenten

5

Edukt 3

HCID 8166Dodecanoyl chlorideHCID 8471TriethylamineHCID 150370494-Aminomethyl-2-triethylsilylfuran2×

Produkt 1

HCID 15037050HCID 15037050, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Dodecanoyl chloride (109 mg, 0.49 mmol) was added to a solution of 4-aminomethyl-2-triethylsilylfuran (Compound 2, 70 mg, 0.33 mmol) and triethylamine (69 microliter, 0.49 mmol) in tetrahydrofuran (3 ml) at room temperature. After stirring at room temperature overnight (ca. 15 hours), most of the solvent was evaporated and the residue was purified by chromatography on preparative silica thin layer plates (developed with 50% ethyl ether/hexane) to give the title amide as a colorless oil.

Aufarbeitung

  1. custommost of the solvent was evaporated
  2. customthe residue was purified by chromatography on preparative silica thin layer plates (developed with 50% ethyl ether/hexane)

Quellen und Nachweise

ORD-Eintrag
ord-0a992ad3e30746749d8f48888e47de8b
Quelldatensatz
uspto-grants-1994_06
Patentnummer
US05322953

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