Triphenylphosphine → (4-Fluoro-3-phenoxyphenyl)methyltriphenylphosphonium chloride

HRID 1110411Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1110411
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][Cl:9])=[CH:4][C:3]=1[O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[C:17]1([P:23]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>O1CCCC1>[Cl-:9].[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][P+:23]([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[CH:4][C:3]=1[O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Komponenten

4

Edukt 2

HCID 11776TriphenylphosphineHCID 135636494-(Chloromethyl)-1-fluoro-2-phenoxybenzene

Produkt 1

HCID 19754846(4-Fluoro-3-phenoxyphenyl)methyltriphenylphosphonium chlorideAusbeute 60,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of 11.8 grams (0.05 mole) of 4-fluoro--3-phenoxyphenylmethyl chloride and 13.1 grams (0.05 mole) of triphenylphosphine in 150 mL of dry tetrahydrofuran was stirred for 72 hours. After this time the reaction mixture was concentrated under reduced pressure to a residual solid. The residue was stirred with diethyl ether and filtered to collect the solid. The solid was washed repeatedly with diethyl ether and dried yielding 15.0 grams of 4-fluoro-3-phenoxyphenylmethyltriphenylphosphonium chloride.

Aufarbeitung

  1. concentrationAfter this time the reaction mixture was concentrated under reduced pressure to a residual solid
  2. filtrationfiltered
  3. customto collect the solid
  4. washThe solid was washed repeatedly with diethyl ether
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-abab2ad225ab43298b07b82f686be21a
Quelldatensatz
uspto-grants-1990_12
Patentnummer
US04975451

Notizen zur Reaktion

Wird geladen…