Tris(hydroxymethyl)aminomethane → Prinomide Tromethamine

HRID 1110851

Reaktionsgleichung

Reaktionsgleichung von HRID 1110851
[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7](=[O:20])[CH:8]([C:11](=[O:19])[NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:9]#[N:10].[NH2:21][C:22]([CH2:27][OH:28])([CH2:25][OH:26])[CH2:23][OH:24]>C(O)C>[NH2:21][C:22]([CH2:27][OH:28])([CH2:25][OH:26])[CH2:23][OH:24].[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7](=[O:20])[CH:8]([C:11](=[O:19])[NH:12][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)[C:9]#[N:10]

Komponenten

4

Edukt 2

HCID 6503Tris(hydroxymethyl)aminomethaneHCID 60352Prinomide

Produkt 1

HCID 3033812Prinomide Tromethamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a suspension of 13.85 g of 1-methyl-beta-oxo-alpha-(phenylcarbamoyl)-2-pyrrolepropionitrile in 350 ml of ethanol is added 6.1 g of tromethamine. The suspension is heated until solution is obtained and the volume is reduced to about 75 ml. The solution is cooled to crystallize the product, the salt is collected, washed with ethanol/ether and dried to yield 1-methyl-beta oxo-alpha-(phenylcarbamoyl)-2-pyrrolepropionitrile tromethamine (1:1) salt of example 1.

Aufarbeitung

  1. temperatureThe suspension is heated until solution
  2. customis obtained
  3. temperatureThe solution is cooled
  4. customto crystallize the product
  5. customthe salt is collected
  6. washwashed with ethanol/ether
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-2f36f66d134640aa9594dbfdce49ba90
Quelldatensatz
uspto-grants-1990_12
Patentnummer
US04977181

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