HCID 19768447, Verbindung → HCID 19768457, Verbindung
Reaktionsgleichung
[ClH:1].[O:2]=[C:3]1[NH:8][CH:7]=[C:6]([C:9]2([NH:15]C=O)[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[CH:5]=[CH:4]1>CO>[ClH:1].[NH2:15][C:9]1([C:6]2[CH:5]=[CH:4][C:3](=[O:2])[NH:8][CH:7]=2)[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]1Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A solution of N-[1-(1,6-dihydro-6-oxo-3-pyridinyl)cyclohexyl]formamide hydrochloride (43.0 g) in 700 ml of methanol was heated at reflux for 17 hours, and then cooled and concentrated. The residual oil was triturated with methanol affording 13.1 g of a white powder. Recrystallization from methanol gave 5.5 g of crystals, m.p. 233°-234° C.
Aufarbeitung
- temperatureat reflux for 17 hours
- temperaturecooled
- concentrationconcentrated
- customThe residual oil was triturated with methanol affording 13.1 g of a white powder
- customRecrystallization from methanol
Quellen und Nachweise
- ORD-Eintrag
- ord-8733b88e750a4a8bb1028a2baa9ffa24
- Quelldatensatz
- uspto-grants-1990_12
- Patentnummer
- US04978663
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