2,2-Dimethoxypropane → (2,2-Dimethyl-5-nitro-1,3-dioxan-5-yl)methanol

HRID 1111258

Reaktionsgleichung

Reaktionsgleichung von HRID 1111258
[OH:1][CH2:2][C:3]([CH2:9][OH:10])([CH2:7][OH:8])[N+:4]([O-:6])=[O:5].CO[C:13](OC)([CH3:15])[CH3:14]>Cl.C(#N)C>[CH3:14][C:13]1([CH3:15])[O:8][CH2:7][C:3]([CH2:9][OH:10])([N+:4]([O-:6])=[O:5])[CH2:2][O:1]1

Komponenten

5

Edukt 2

HCID 64952,2-DimethoxypropaneHCID 31337Tris(hydroxymethyl)nitromethane

Produkt 1

HCID 300859(2,2-Dimethyl-5-nitro-1,3-dioxan-5-yl)methanolAusbeute 82 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidKatalysatorHCID 6342AcetonitrileLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To a 250 ml round bottom flask equipped with a stir bar was added 5 g (0.03 mol) tris(hydroxymethyl) nitromethane, 3.75 g (0.36 mol) 2,2-dimethoxypropane, 100 ml acetonitrile and 6 drops concentrated hydrochloric acid. The reaction was heated to 80° C. for 18 hours. After cooling to room temperature tte volatiles were removed in vacuo to give a white solid 2,2-dimethyl-5-hydroxy methyl-5-nitro-1,3-dioxane in 82% yield.

Aufarbeitung

  1. customTo a 250 ml round bottom flask equipped with a stir bar
  2. temperatureAfter cooling to room temperature tte volatiles
  3. customwere removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-4cb4e03e4c7a4972819b706c2c63d137
Quelldatensatz
uspto-grants-1990_12
Patentnummer
US04978793

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