Methanol → 1-(3'-Trifluoromethylbenzoyl)-2-methoxypiperidine

HRID 1111680Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1111680
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:4]=[C:5]([CH:14]=[CH:15][CH:16]=1)[C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1)=[O:7].[CH3:19][OH:20]>F[B-](F)(F)F.C[N+](C)(C)C>[F:18][C:2]([F:17])([F:1])[C:3]1[CH:4]=[C:5]([CH:14]=[CH:15][CH:16]=1)[C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[O:20][CH3:19])=[O:7]

Komponenten

4

Edukt 2

HCID 887MethanolHCID 29801401-[3-(Trifluoromethyl)benzoyl]piperidine2×

Produkt 1

HCID 213228551-(3'-Trifluoromethylbenzoyl)-2-methoxypiperidineAusbeute 88,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 12621Tetramethylammonium tetrafluoroborateKatalysator

Versuchsvorschrift

In the same manner as in Example 5, there are electrolyzed 13.5 g of 1-(3'-trifluoromethylbenzoyl)-piperidine and 84.1 g of methanol in the presence of 0.11 g of tetramethylammonium tetrafluoroborate as conducting salt. After throughput of 2.5 Faraday per mol of 1-(3'-trifluoromethylbenzoyl)-piperidine the current is switched off. The calculated mean cell voltage is 34.1 volts. Work-up of the electrolysis solution gives 13.3 g of 1-(3'-trifluoromethylbenzoyl)-2-methoxypiperidine (boiling point 75°-80° C./0.2 mm Hg; nD25 = 1.4905) are obtained which corresponds to a product yield of 88.8% and a current efficiency of 70.6%.

Quellen und Nachweise

ORD-Eintrag
ord-91f50af60b6a434aad6463e3d56ab4df
Quelldatensatz
uspto-grants-1978_10
Patentnummer
US04118500

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