Methanol → 4-Chloro-2-(3-trifluoromethylphenoxy)-benzoic acid methyl ester

HRID 1111821Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1111821
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[CH:3]=1.S(=O)(=O)(O)O.[CH3:27]O>>[CH3:27][O:7][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:2]([Cl:1])=[CH:3][C:4]=1[O:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:19])([F:20])[F:21])[CH:13]=1

Komponenten

4

Edukt 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 227678684-Chloro-2-(3-trifluoromethyl-phenoxy)-benzoic acid

Produkt 1

HCID 540086294-Chloro-2-(3-trifluoromethylphenoxy)-benzoic acid methyl ester

Versuchsvorschrift

136 G. of 4-chloro-2-(3-trifluoromethyl-phenoxy)-benzoic acid are boiled at reflux for 2.5 hours in a mixture of 1000 ml. of methanol and 100 ml. of concentrated sulfuric acid. After concentration of the mixture under vacuum, the residue is poured on to ice and extracted with benzene. The benzene extracts are washed with water, aqueous sodium bicarbonate solution and again with water. After evaporation of the benzene, there is obtained 4-chloro-2-(3-trifluoromethylphenoxy)-benzoic acid methyl ester in the form of an oil.

Aufarbeitung

  1. temperatureat reflux for 2.5 hours in a mixture of 1000 ml
  2. additionAfter concentration of the mixture under vacuum, the residue is poured on to ice
  3. extractionextracted with benzene
  4. washThe benzene extracts are washed with water, aqueous sodium bicarbonate solution and again with water
  5. customAfter evaporation of the benzene

Quellen und Nachweise

ORD-Eintrag
ord-05896763b8d34a4e8fa80aeac674a648
Quelldatensatz
uspto-grants-1978_10
Patentnummer
US04118572

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