Tetrahydrofuran → (S)-N-Carbobenzyloxy-3-(3,4-diformyloxyphenyl)-2-methylalanine

Beteiligte Stoffe

Reaktionsschritte

A solution of (S)-N-carbobenzyloxy-3-(3,4-dihydroxyphenyl)-2-methylalanine (0.35 g, 1 mmol) and acetic formic anhydride (0.36 g, 4 mmol) in anhydrous tetrahydrofuran (5 ml) is stirred 24 hours at 20°-25° under dry N2. The solvent is evaporated in vacuo and the residue is dried further at 0.1mm/25° for 2 hours. The product (A) (0.4 g, 100%) is obtained as an oil.

Herkunft & Nachweise