Benzylamine → 1-Benzyl-3-phenylurea

HRID 1112332

Reaktionsgleichung

Reaktionsgleichung von HRID 1112332
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:9]1([NH:15][C:16](OC2C(O)=C(C3C=CC=CC=3)S(=O)(=O)C=2C2C=CC=CC=2)=[O:17])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>C(OCC)(=O)C>[CH2:1]([NH:8][C:16]([NH:15][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 7504BenzylamineHCID 227636553-(Phenylcarbamyloxy)-4-hydroxy-2,5-diphenylthiophene-1,1-dioxide

Produkt 1

HCID 2803631-Benzyl-3-phenylurea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

540 mg of benzylamine are added to 2.1 g of 3-(N-phenylcarbamyloxy)-4-hydroxy-2,5-diphenylthiophene-1,1-dioxide in 20 ml of ethyl acetate. The solution is boiled under reflux for 1 hour and then washed three times with 25 ml of concentrated aqueous NaHCO3 solution and three times with 20% strength aqueous citric acid solution. The wash liquors are extracted with ethyl acetate and the combined organic phases are dried over magnesium sulfate. After evaporating the filtrate, the crystalline residue is recrystallized from dilute ethanol.

Aufarbeitung

  1. temperatureunder reflux for 1 hour
  2. washwashed three times with 25 ml of concentrated aqueous NaHCO3 solution and three times with 20% strength aqueous citric acid solution
  3. extractionThe wash liquors are extracted with ethyl acetate
  4. dry with materialthe combined organic phases are dried over magnesium sulfate
  5. customAfter evaporating the filtrate
  6. customthe crystalline residue is recrystallized from dilute ethanol

Quellen und Nachweise

ORD-Eintrag
ord-195cfb6f7ac3451089078aa7bd2aced2
Quelldatensatz
uspto-grants-1978_10
Patentnummer
US04122090

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