Ethyl Acetate → cis-3-Azido-4-oxo-2-azetidinylmethyl bromide

HRID 1112344Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1112344
S(C1C=CC(C)=CC=1)(O[CH2:5][C@H:6]1[C@@H:9]([N:10]=[N+:11]=[N-:12])[C:8](=[O:13])[NH:7]1)(=O)=O.[Li+].[Br-:22].C(OCC)(=O)C>CN(C)C=O>[N:10]([C@H:9]1[C:8](=[O:13])[NH:7][C@H:6]1[CH2:5][Br:22])=[N+:11]=[N-:12]

Komponenten

5

Edukt 3

HCID 8857Ethyl AcetateHCID 82050Lithium BromideHCID 86734335HCID 86734335, Verbindung

Produkt 1

HCID 86736078cis-3-Azido-4-oxo-2-azetidinylmethyl bromide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A degassed solution of cis-3-azido-4-oxo-2-azetidinylmethyl tosylate (0.41 g, 1.4 mmol) in dimethylformamide (5 ml) was heated to 90° with LiBr (0.43 g, 5 mmol) for 4 hours. The reaction was poured into ethyl acetate and washed copiously with water. The dried solution was evaporated to give the title compound.

Aufarbeitung

  1. washwashed copiously with water
  2. customThe dried solution was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-7f9dc7402b6f40cfba065dd4816442d6
Quelldatensatz
uspto-grants-1978_10
Patentnummer
US04122086

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