Clofibric Acid → Apovincamine clofibrate

HRID 1112361

Reaktionsgleichung

[CH3:1][CH2:2][C@:3]12[CH:19]=[C:18]([C:20]([O:22][CH3:23])=[O:21])[N:17]3[C:9]4=[C:10]([CH2:24][CH2:25][N:7]([C@@H:8]14)[CH2:6][CH2:5][CH2:4]2)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=13.[CH3:26][C:27]([O:32][C:33]1[CH:34]=[CH:35][C:36]([Cl:39])=[CH:37][CH:38]=1)([C:29]([OH:31])=[O:30])[CH3:28]>>[CH3:1][CH2:2][C@:3]12[CH:19]=[C:18]([C:20]([O:22][CH3:23])=[O:21])[N:17]3[C:9]4=[C:10]([CH2:24][CH2:25][N:7]([C@@H:8]14)[CH2:6][CH2:5][CH2:4]2)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=13.[CH3:1][CH2:2][O:30][C:29]([C:27]([O:32][C:33]1[CH:38]=[CH:37][C:36]([Cl:39])=[CH:35][CH:34]=1)([CH3:26])[CH3:28])=[O:31]

Komponenten

Edukt 2

HCID 2797Clofibric Acid

HCID 71204Apovincamine

Produkt 1

HCID 70622092Apovincamine clofibrateAusbeute 121 %

Versuchsvorschrift

The preceding example is repeated starting from 3.36 g of apovincamine and 2.14 g of clofibric acid. The final product (3.5 g) is a low melting solid, m.p. 65° C., which is insoluble in water and soluble in alcohol, with an apovincamine content of 61%.

Quellen und Nachweise

ORD-Eintrag: ord-ef774ae28b334877bd8c60360e247aac
Quelldatensatz: uspto-grants-1978_10
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04122179

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