Sodium Hydroxide → 2-[N-(3-Carboxypropyl)-isobutyramido]-4-methyloxazole

HRID 1112395Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1112395
[C:1]([CH2:6][CH2:7][CH2:8][N:9]([C:15]1[O:16][CH:17]=[C:18]([CH3:20])[N:19]=1)[C:10](=[O:14])[CH:11]([CH3:13])[CH3:12])([O:3]CC)=[O:2].[OH-].[Na+]>C(O)C>[C:1]([CH2:6][CH2:7][CH2:8][N:9]([C:15]1[O:16][CH:17]=[C:18]([CH3:20])[N:19]=1)[C:10](=[O:14])[CH:11]([CH3:13])[CH3:12])([OH:3])=[O:2]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 213236572[N-(3-carbethoxypropyl)-isobutyramido]-4-methyloxazole

Produkt 1

HCID 213236712-[N-(3-Carboxypropyl)-isobutyramido]-4-methyloxazoleAusbeute 57,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 2[ N-(3-carbethoxypropyl)-isobutyramido]-4-methyloxazole (9.9 g., 0.035 mol.) prepared in a manner similar to that described in Example 44 was dissolved in ethanol (100 ml.) and N NaOH solution (35 ml.) and the solution was stirred for 20 hours at ambient temperature. The solution was evaporated and the residue was dissolved in water, washed with ether, acidified and extracted with ether. The extract was dried and evaporated and the residue was recrystallised from benzene-petrol to give the product 5.1 g., m.p. 81°-82° C.

Aufarbeitung

  1. customThe solution was evaporated
  2. dissolutionthe residue was dissolved in water
  3. washwashed with ether
  4. extractionextracted with ether
  5. customThe extract was dried
  6. customevaporated
  7. customthe residue was recrystallised from benzene-petrol

Quellen und Nachweise

ORD-Eintrag
ord-8693ab25ec2642278b3325a6d8f8a77d
Quelldatensatz
uspto-grants-1978_10
Patentnummer
US04122183

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