Ethanolamine → 3-(2-Hydroxyethylamino)-1-tetradecylthio-2-propanol

HRID 1117Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1117
[CH2:1]([CH2:3][NH2:4])[OH:2].[CH2:5]([S:19][CH2:20][CH:21]1[O:23][CH2:22]1)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]>C(O)C>[OH:2][CH2:1][CH2:3][NH:4][CH2:22][CH:21]([OH:23])[CH2:20][S:19][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

Komponenten

4

Edukt 2

HCID 700EthanolamineHCID 134179241-Tetradecylthio-2,3-epoxypropane

Produkt 1

HCID 134651593-(2-Hydroxyethylamino)-1-tetradecylthio-2-propanolAusbeute 91 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

A 300-ml flask equipped with a stirrer and dropping funnel was charged with 61.1 g (1 mol) of ethanolamine and 61 g of ethanol. While stirring the contents at 80° C., a solution of 14.3 g (50 mmol) of 1-tetradecylthio-2,3-epoxypropane in 30 g ethanol was added dropwise over 3 hours. After completion of the dropping, the resultant reaction mixture was concentrated under reduced pressure, and the residue was recrystallized from hexane, thereby obtaining 15.8 g (yield: 91%) of the title compound (IIe-1).

Aufarbeitung

  1. customA 300-ml flask equipped with a stirrer
  2. customAfter completion of the dropping, the resultant reaction mixture
  3. concentrationwas concentrated under reduced pressure
  4. customthe residue was recrystallized from hexane

Quellen und Nachweise

ORD-Eintrag
ord-050e689426f84409ae62ef62ee510e60
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05723497

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