Ethyl Bromide → 2-Ethoxybenzonitrile
Reaktionsgleichung
[OH:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].C(=O)([O-])[O-].[K+].[K+].[CH2:16](Br)[CH3:17]>CC(C)=O>[CH2:16]([O:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5])[CH3:17]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
25 g (210 mmol) of 2-hydroxybenzonitrile, 87 g of potassium carbonate and 34.3 g (314.8 mmol) of ethyl bromide are refluxed in 500 ml of acetone overnight. The solid is filtered off, the solvent is removed under reduced pressure and the residue is distilled under reduced pressure. This gives 30.0 g (97%) of a colorless liquid.
Aufarbeitung
- filtrationThe solid is filtered off
- customthe solvent is removed under reduced pressure
- distillationthe residue is distilled under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-b6831fca491149af9b43e92a72273938
- Quelldatensatz
- uspto-grants-2006_08
- Patentnummer
- US07098207B2
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