Fluoroquinolonic acid → 1-Cyclopropyl-6-fluoro-1,4-dihydro-7-(3'-acetamido-5'-methylpvrrolidin-1-yl)-4-oxo-quinoline-3-carboxylic acid

HRID 11290Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 11290
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:15])=[C:11](Cl)[CH:12]=3)[C:7](=[O:16])[C:6]([C:17]([OH:19])=[O:18])=[CH:5]2)[CH2:3][CH2:2]1.[C:20]([NH:23][CH:24]1[CH2:28][CH:27]([CH3:29])[NH:26][CH2:25]1)(=[O:22])[CH3:21]>>[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:15])=[C:11]([N:26]4[CH:27]([CH3:29])[CH2:28][CH:24]([NH:23][C:20](=[O:22])[CH3:21])[CH2:25]4)[CH:12]=3)[C:7](=[O:16])[C:6]([C:17]([OH:19])=[O:18])=[CH:5]2)[CH2:3][CH2:2]1

Komponenten

3

Edukt 2

HCID 483180Fluoroquinolonic acidHCID 199572063-Acetamido-5-methylpyrrolidine

Produkt 1

HCID 101347991-Cyclopropyl-6-fluoro-1,4-dihydro-7-(3'-acetamido-5'-methylpvrrolidin-1-yl)-4-oxo-quinoline-3-carboxylic acid

Versuchsvorschrift

The condensation of 1-cyclopropyl-6-fluoro-7-chloro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid with 3-acetamido-5-methylpyrrolidine in a similar manner as described in example 1 give the titled product. Yield (68%), m.p 270–72° C., C20H22FN3O4, m/z 388 (M+1).

Quellen und Nachweise

ORD-Eintrag
ord-52e4e58da95a46789156c6f37fe17043
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07098219B2

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