5-Amino-1-(2,4-difluorophenyl)-6,7,8-trifluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid → 5-Amino-1-(2',4'-difluorophenyl)-6,8-difluoro-1,4-dihydro-7-(3'-hydroxy-5'-methylpyrrolidin-1-yl)-4-oxo-quinoline-3-carboxylic acid

HRID 11294

Reaktionsgleichung

Reaktionsgleichung von HRID 11294
[NH2:1][C:2]1[C:11]([F:12])=[C:10](F)[C:9]([F:14])=[C:8]2[C:3]=1[C:4](=[O:26])[C:5]([C:23]([OH:25])=[O:24])=[CH:6][N:7]2[C:15]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=1[F:22].[OH:27][CH:28]1[CH2:32][CH:31]([CH3:33])[NH:30][CH2:29]1>>[NH2:1][C:2]1[C:11]([F:12])=[C:10]([N:30]2[CH:31]([CH3:33])[CH2:32][CH:28]([OH:27])[CH2:29]2)[C:9]([F:14])=[C:8]2[C:3]=1[C:4](=[O:26])[C:5]([C:23]([OH:25])=[O:24])=[CH:6][N:7]2[C:15]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=1[F:22]

Komponenten

3

Edukt 2

HCID 148965525-Amino-1-(2,4-difluorophenyl)-6,7,8-trifluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acidHCID 219737795-Methylpyrrolidin-3-ol

Produkt 1

HCID 101611315-Amino-1-(2',4'-difluorophenyl)-6,8-difluoro-1,4-dihydro-7-(3'-hydroxy-5'-methylpyrrolidin-1-yl)-4-oxo-quinoline-3-carboxylic acidAusbeute 64 %

Versuchsvorschrift

The condensation of 5-Amino-1-(2′,4′-difluorophenyl)-6,7,8-trifluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid with 3-hydroxy-5-methylpyrrolidine in a similar manner as described in example 1 gave the titled product. Yield 64%, m.p ° C., C21H17F4N3O4, m/z 453. (M+1)

Quellen und Nachweise

ORD-Eintrag
ord-8eceacde241b40df8f1b4079320c969f
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07098219B2

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