Phenol → 3-Nitro-2-phenoxypyridine

HRID 11338

Reaktionsgleichung

Reaktionsgleichung von HRID 11338
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[C:11]1([OH:17])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[N+:8]([C:7]1[C:2]([O:17][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[N:3][CH:4]=[CH:5][CH:6]=1)([O-:10])=[O:9]

Komponenten

3

Edukt 2

HCID 996PhenolHCID 796132-Chloro-3-nitropyridine

Produkt 1

HCID 9018963-Nitro-2-phenoxypyridine

Versuchsvorschrift

In step (3) of Reaction Scheme IV a 2-chloro-3-nitropyridine of Formula XXIV is reacted with phenol to provide a 3-nitro-2-phenoxypyridine of Formula XXV. Phenol is reacted with sodium hydride in a suitable solvent such as diglyme or tetrahydrofuran to form the phenoxide. The phenoxide is then reacted at ambient temperature, or optionally at an elevated temperature, with a compound of Formula XXIV.

Quellen und Nachweise

ORD-Eintrag
ord-8fb2123c92c44b8f9bd0be7e995b3f32
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07098221B2

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