(z)-2-Ethoxy-3-(1h-indol-4-yl)-acrylic acid ethyl ester → Rac-2-ethoxy-3-(1h-indol-4-yl)-propionic acid ethyl ester

Beteiligte Stoffe

Reaktionsschritte

A suspension of 15.0 g of (Z)-2-ethoxy-3-(1H-indol-4-yl)-acrylic acid ethyl ester in 250 ml of EtOH and 3.08 g of Pd/C (10%) was hydrogenated at 22° C. for 2 h, after which time hydrogen uptake ceased. The suspension was filtered, the filtrate evaporated and the residue chromatographed on silica gel (eluent: gradient of hexane and ethyl acetate) to give 12.28 g of the title compound as a light brown oil.

Herkunft & Nachweise