Hydrochloric Acid → 2-Methylindol-4-yloxyacetic Acid

HRID 11410Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 11410
C[O:2][C:3](=[O:16])[CH:4]([O:6][C:7]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:8]=1[CH:9]=[CH:10][NH:11]2)[CH3:5].O1CCOCC1.[OH-].[Na+].Cl>CO>[CH3:5][CH:4]([O:6][C:7]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:8]=1[CH:9]=[CH:10][NH:11]2)[C:3]([OH:16])=[O:2]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 312751,4-DioxaneHCID 691303762-Methylindol-4-yloxyacetic Acid Methyl Ester

Produkt 1

HCID 695893972-Methylindol-4-yloxyacetic AcidAusbeute 69,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 2-methylindol-4-yloxyacetic acid methyl ester (5.4 g) in methanol (18 ml)—dioxane (36 ml) was added 5N aqueous solution of sodium hydroxide (15 ml), and the mixture was stirred at room temperature for 1 hour. To the reaction solution was added 2N hydrochloric acid to give the title compound (3.5 g) having the following physical data.

Quellen und Nachweise

ORD-Eintrag
ord-9780cbde62544c4190fa07986e5ceffd
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07098234B2

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