Ammonia → 2-(Carbamoylamino)thiophene-3-carboxamide

HRID 11421

Reaktionsgleichung

Reaktionsgleichung von HRID 11421
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].ClC(Cl)(Cl)[C:12]([N:14]=C=O)=[O:13].N>C(#N)C.CO>[NH2:14][C:12]([NH:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8])=[O:13]

Komponenten

6

Edukt 3

HCID 222AmmoniaHCID 76400Trichloroacetyl isocyanateHCID 6994952-Aminothiophene-3-carboxamide

Produkt 1

HCID 111714022-(Carbamoylamino)thiophene-3-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

2-Amino-3-thiophencarboxamide (0.44 g) was suspended in acetonitrile (25 ml) and trichloroacetylisocyanate (0.2 ml) added dropwise with stirring over 10 minutes. Stirring was continued for a further 3 h at room temperature and then a solution of ammonia in methanol (10 ml of a 2M solution) was added and stirring was continued for a further 2 h. The solvent was evaporated and the residue treated with water. The resultant solid was filtered off and washed with more water. Trituration with ether gave the title urea (0.2 g).

Aufarbeitung

  1. stirringStirring
  2. waitwas continued for a further 3 h at room temperature
  3. stirringstirring
  4. waitwas continued for a further 2 h
  5. customThe solvent was evaporated
  6. additionthe residue treated with water
  7. filtrationThe resultant solid was filtered off
  8. washwashed with more water

Quellen und Nachweise

ORD-Eintrag
ord-f0c8411110a14024be0381e63896f360
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07098240B2

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