Benzenamine, 4-(4-morpholinyl)- → HCID 178418945, Verbindung

HRID 11538

Reaktionsgleichung

Reaktionsgleichung von HRID 11538
O[CH:2]=[C:3]1[C:11]2[C:6](=[CH:7][C:8]([C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[CH:13]=3)=[CH:9][CH:10]=2)[NH:5][C:4]1=[O:20].[N:21]1([C:27]2[CH:32]=[CH:31][C:30]([NH2:33])=[CH:29][CH:28]=2)[CH2:26][CH2:25][O:24][CH2:23][CH2:22]1>O1CCCC1>[CH3:19][O:18][C:14]1[CH:13]=[C:12]([C:8]2[CH:7]=[C:6]3[C:11]([C:3](=[CH:2][NH:33][C:30]4[CH:29]=[CH:28][C:27]([N:21]5[CH2:22][CH2:23][O:24][CH2:25][CH2:26]5)=[CH:32][CH:31]=4)[C:4](=[O:20])[NH:5]3)=[CH:10][CH:9]=2)[CH:17]=[CH:16][CH:15]=1

Komponenten

4

Edukt 2

HCID 75655Benzenamine, 4-(4-morpholinyl)-HCID 178418992HCID 178418992, Verbindung

Produkt 1

HCID 178418945HCID 178418945, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

The named compound is prepared by refluxing 0.020 gms E & Z 3-hydroxymethylene-6-(3-methoxy-phenyl)-1,3-dihydro-indol-2-one with 0.020 gms. 4-morpholin-4-yl-phenylamine in tetrahydrofuran (0.33 mL) for 2 days. Following cooling to room temperature, solvent evaporation in vacuo, trituration with isopropanol and filtration the reaction yields the named compound as a solid in the amount of 15.7 mg.

Aufarbeitung

  1. customThe named compound is prepared
  2. customsolvent evaporation in vacuo, trituration
  3. filtrationwith isopropanol and filtration the reaction

Quellen und Nachweise

ORD-Eintrag
ord-e83cfed6237146ecaad1c4492e25a9ff
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07098236B2

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