HCID 20435989, Verbindung → HCID 20435943, Verbindung

HRID 1154035Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1154035
[CH3:1][C:2]1([CH2:17][CH2:18][O:19]C2CCCCO2)[C:14](=[O:15])[N:5]2[CH2:6][CH:7]=[CH:8][CH:9]([C:10]([O:12][CH3:13])=[O:11])[N:4]2[C:3]1=[O:16]>Cl.CO>[OH:19][CH2:18][CH2:17][C:2]1([CH3:1])[C:14](=[O:15])[N:5]2[CH2:6][CH:7]=[CH:8][CH:9]([C:10]([O:12][CH3:13])=[O:11])[N:4]2[C:3]1=[O:16]

Komponenten

4

Edukt 1

HCID 20435989HCID 20435989, Verbindung

Produkt 1

HCID 20435943HCID 20435943, VerbindungAusbeute 97 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 3.52 g (0.01 mol) of methyl 2,3,5,8-tetrahydro-2-methyl-1,3-dioxo-2[2-(tetrahydro-2-pyranyloxy)ethyl]-1H-pyrazolo[1,2-a]pyridazine-5-carboxylate in 50 ml of 1M hydrochloric acid and 50 ml of methanol was stirred at room temperature for 1.5 hours. The solvent was removed by evaporation in vacuo. The solid residue was taken up in dichloromethane, dried over magnesium sulfate and evaporated to give 2.6 g (97%) of methyl 2,3,5,8-tetrahydro-2-(2-hydroxyethyl)-2-methyl-1,3-dioxo-1H-pyrazolo[1,2-a]pyridazine-5-carboxylate having a melting point of 97°-99° C. (from diethyl ether).

Aufarbeitung

  1. customThe solvent was removed by evaporation in vacuo
  2. dry with materialdried over magnesium sulfate
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-4d5f6c5945fa446d9528c516b17a3c9e
Quelldatensatz
uspto-grants-1984_12
Patentnummer
US04487929

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