Sodium Hydroxide → N-[3-(4-phenyl-1H-imidazol-1-yl)propyl]-2-furanecarboxamide

HRID 1154335Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1154335
[C:1]1([C:7]2[N:8]=[CH:9][N:10]([CH2:12][CH2:13][CH2:14][NH2:15])[CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+].[O:18]1[CH:22]=[CH:21][CH:20]=[C:19]1[C:23](Cl)=[O:24]>C(Cl)Cl>[C:1]1([C:7]2[N:8]=[CH:9][N:10]([CH2:12][CH2:13][CH2:14][NH:15][C:23]([C:19]3[O:18][CH:22]=[CH:21][CH:20]=3)=[O:24])[CH:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 682422-Furancarbonyl chlorideHCID 135889123-(4-Phenyl-1H-imidazol-1-yl)propan-1-amine

Produkt 1

HCID 13371090N-[3-(4-phenyl-1H-imidazol-1-yl)propyl]-2-furanecarboxamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

A mixture of 2.0 g. of 4-phenyl-1H-imidazole-1-propanamine, 50 ml. of methylenechloride and 10 ml. of 1N sodium hydroxide was stirred and 2.0 ml. of 2-furoyl chloride was added. The mixture was stirred for eighteen hours, methylene chloride was added and the layers were separated. The organic layer was washed with water, dried over magnesium sulfate and concentrated. The residue was washed onto a filter with diethyl ether, giving the desired product, m.p. 120°-122° C.

Aufarbeitung

  1. additionA mixture of 2.0 g
  2. customthe layers were separated
  3. washThe organic layer was washed with water
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated
  6. washThe residue was washed onto
  7. filtrationa filter with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-3c253e52698e49da9182f65322d084c1
Quelldatensatz
uspto-grants-1984_12
Patentnummer
US04489089

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