m-Chloroperbenzoic acid → HCID 20561000, Verbindung

HRID 1155522Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1155522
ClC1C=C(C=CC=1)C(OO)=[O:6].[Cl:12][C:13]1[CH:22]=[C:21]2[C:16]([C:17](=[O:27])[C:18]([S:24]([CH3:26])=[O:25])=[CH:19][N:20]2[CH3:23])=[CH:15][CH:14]=1>C(Cl)(Cl)Cl>[Cl:12][C:13]1[CH:22]=[C:21]2[C:16]([C:17](=[O:27])[C:18]([S:24]([CH3:26])(=[O:6])=[O:25])=[CH:19][N:20]2[CH3:23])=[CH:15][CH:14]=1

Komponenten

4

Edukt 2

HCID 70297m-Chloroperbenzoic acidHCID 202591227-Chloro-1-methyl-3-(methylsulfinyl)-4(1H)-quinolinone

Produkt 1

HCID 20561000HCID 20561000, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel2×

Versuchsvorschrift

A solution of 3-chloroperoxybenzoic acid (85%, 6.75 g.) in chloroform (70 ml.) was added dropwise to a stirred solution of 7-chloro-1-methyl-3-methylsulphinyl-4-quinolone (6.25 g.) in chloroform (150 ml.). The resulting solution was stirred at room temperature for 2 hours and then washed repeatedly with saturated aqueous sodium carbonate solution to remove peroxide. The resulting solution was dried over anhydrous magnesium sulphate and then evaporated. The solid residue was crystallised from ethanol using charcoal to give 7-chloro-1-methyl-3-methylsulphonyl-4-quinolone, m.p. 241°-242°.

Aufarbeitung

  1. washwashed repeatedly with saturated aqueous sodium carbonate solution
  2. customto remove peroxide
  3. dry with materialThe resulting solution was dried over anhydrous magnesium sulphate
  4. customevaporated
  5. customThe solid residue was crystallised from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-583592bfb1e041c3ab78cc346d5a5aef
Quelldatensatz
uspto-grants-1981_11
Patentnummer
US04302460

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