Piperidine, 1-methyl-4-(4-nitrophenoxy)-4-phenyl- → Piperidine, 4-(p-aminophenoxy)-1-methyl-4-phenyl-

HRID 1156028

Reaktionsgleichung

Reaktionsgleichung von HRID 1156028
[CH3:1][N:2]1[CH2:7][CH2:6][C:5]([O:14][C:15]2[CH:20]=[CH:19][C:18]([N+:21]([O-])=O)=[CH:17][CH:16]=2)([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:4][CH2:3]1>C(O)C.[Pt]>[NH2:21][C:18]1[CH:19]=[CH:20][C:15]([O:14][C:5]2([C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=3)[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH2:6]2)=[CH:16][CH:17]=1

Komponenten

4

Edukt 1

HCID 3060390Piperidine, 1-methyl-4-(4-nitrophenoxy)-4-phenyl-

Produkt 1

HCID 3060392Piperidine, 4-(p-aminophenoxy)-1-methyl-4-phenyl-Ausbeute 74,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23939PlatinumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

51 g of 1-methyl-4-(4-nitrophenoxy)-4-phenylpiperidine are dissolved in 1.5 liters of ethanol and are hydrogenated under a hydrogen pressure of 1 atmosphere in the presence of platinum. The catalyst is filtered off, the filtrate is concentrated to 300 ml and crystals (which have separated out) are collected. 34.3 g of the title compound of m.p. 173° to 174° C. are obtained by successive concentration of the filtrate.

Aufarbeitung

  1. filtrationThe catalyst is filtered off
  2. concentrationthe filtrate is concentrated to 300 ml and crystals (which
  3. customhave separated out)
  4. customare collected

Quellen und Nachweise

ORD-Eintrag
ord-8ad115a3f6d441419d4866e6503e5fc5
Quelldatensatz
uspto-grants-1982_06
Patentnummer
US04333942

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