Ammonia → 1,5,6,7-Tetrahydro-4H-indol-4-one

Reaktionsgleichung

C(O[CH:4]1[CH2:12][C:11]2[C:10](=O)[CH2:9][CH2:8][CH2:7][C:6]=2[O:5]1)C.[NH3:14]>>[O:5]=[C:6]1[CH2:7][CH2:8][CH2:9][C:10]2[NH:14][CH:4]=[CH:12][C:11]1=2

Komponenten

Edukt 2

HCID 222Ammonia

HCID 110630394(2H)-Benzofuranone, 2-ethoxy-3,5,6,7-tetrahydro-

Produkt 1

HCID 2802291,5,6,7-Tetrahydro-4H-indol-4-oneAusbeute 54 %

Reaktionsbedingungen

Temperatur: 100 °C

Versuchsvorschrift

96.5 mg of 2-ethoxy-4-oxo-2,3,4,5,6,7-hexahydrocoumarone and 1.5 ml of 28% aqueous ammonia were admixed in a glass tube which was sealed and heated at 100° C. for 14 hours. The reaction mixture was treated in the same manner as Example 11 to give 38.4 mg of 4-oxo-4,5,6,7-tetrahydroindole (yield 54%).

Aufarbeitung

customwhich was sealed
additionThe reaction mixture was treated in the same manner as Example 11

Quellen und Nachweise

ORD-Eintrag: ord-116ca53683b0484f8e251164ad5c75b5
Quelldatensatz: uspto-grants-1982_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04336202

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