Methyl iodide → Hexahydro-3a-(m-methoxyphenyl)-1,1-dimethyl-indolinium iodide

HRID 1156550Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1156550
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]23[CH2:17][CH2:16][CH2:15][CH2:14][CH:13]2[N:12]([CH3:18])[CH2:11][CH2:10]3)[CH:6]=[CH:7][CH:8]=1.[CH3:19][I:20]>CC(C)=O>[I-:20].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]23[CH2:17][CH2:16][CH2:15][CH2:14][CH:13]2[N+:12]([CH3:19])([CH3:18])[CH2:11][CH2:10]3)[CH:6]=[CH:7][CH:8]=1

Komponenten

4

Edukt 2

HCID 6328Methyl iodideHCID 12838428Hexahydro-3a-(m-methoxyphenyl)-1-methylindoline

Produkt 1

HCID 12838431Hexahydro-3a-(m-methoxyphenyl)-1,1-dimethyl-indolinium iodide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

4.6 g of hexahydro-3a-(m-methoxyphenyl)-1-methylindoline are dissolved in 100 ml of acetone, and the solution is treated with 10 ml of methyl iodide. The mixture is boiled at reflux for 10 hours. Thereafter, the solvent is removed by distillation, and the residue is recrystallized from acetone. The hexahydro-3a-(m-methoxyphenyl)-1,1-dimethyl-indolinium iodide obtained melts at 195°-196° C.

Aufarbeitung

  1. temperatureat reflux for 10 hours
  2. customThereafter, the solvent is removed by distillation
  3. customthe residue is recrystallized from acetone

Quellen und Nachweise

ORD-Eintrag
ord-00ede6a5e2034d25a099d2b8442960eb
Quelldatensatz
uspto-grants-1982_06
Patentnummer
US04336268

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