Isoproterenone hydrochloride → HCID 20535380, Verbindung

HRID 1156692

Reaktionsgleichung

Reaktionsgleichung von HRID 1156692
Cl.[CH:2]([NH:5][CH2:6][C:7]([C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[C:11]([OH:16])[CH:10]=1)=[O:8])([CH3:4])[CH3:3].[Cl:17][C:18]1[C:26]([O:27][CH3:28])=[C:25]([CH3:29])[CH:24]=[CH:23][C:19]=1[C:20](Cl)=[O:21]>>[CH:2]([NH:5][CH2:6][C:7]([C:9]1[CH:14]=[CH:13][C:12]([O:15][C:20](=[O:21])[C:19]2[CH:23]=[CH:24][C:25]([CH3:29])=[C:26]([O:27][CH3:28])[C:18]=2[Cl:17])=[C:11]([OH:16])[CH:10]=1)=[O:8])([CH3:4])[CH3:3]

Komponenten

3

Edukt 2

HCID 2830496Isoproterenone hydrochlorideHCID 205353932-Chloro-3-methoxy-4-methylbenzoyl chloride

Produkt 1

HCID 20535380HCID 20535380, Verbindung

Versuchsvorschrift

Following the procedure described above in Example 58A but using 3,4-dihydroxyphenyl isopropylaminomethyl ketone hydrochloride instead of 3,4-dihydroxyphenyl tert-butylaminomethyl ketone hydrochloride and 2-chloro-3-methoxy-4-methylbenzoyl chloride instead of isovaleryl chloride, there is obtained 3-hydroxy-4-(2-chloro-3-methoxy-4-methylbenzoyloxy)phenyl isopropylaminomethyl ketone; and by interaction of this base with hydrochloric acid there is obtained the hydrochloride salt. When this hydrochloride is catalytically hydrogenated, using a procedure similar to that described above in Example 2B, there is obtained 3-hydroxy-4-(2-chloro-3-methoxy-4-methylbenzoyloxy)-alpha-(isopropylaminomethyl)benzyl alcohol hydrochloride.

Quellen und Nachweise

ORD-Eintrag
ord-5fe4838db46244f9b4261a8d4b66cd52
Quelldatensatz
uspto-grants-1982_06
Patentnummer
US04336400

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