HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1156717Erstellt: 26. Oktober 2026
Trichloroacetyl chloride → 5-(N-Methyl-Trichloroacetamido)-3-Trichloromethyl-1,2,4-Thiadiazole
https://huagongshe.com/reaction/1156717
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Trichloroacetyl chloride | HCID 6420 | — |
| Edukt | N-Methyl-3-(trichloromethyl)-1,2,4-thiadiazol-5-amine | HCID 13150493 | — |
| Lösungsmittel | Toluene | HCID 1140 | — |
| Produkt | 5-(N-Methyl-Trichloroacetamido)-3-Trichloromethyl-1,2,4-Thiadiazole | HCID 12851602 | 92% |
Reaktionsschritte
A solution of 5.8 grams (0.02 mole) 5-methylamino-3-trichloromethyl-1,2,4-thiadiazole and 9.0 grams (0.05 mole) trichloroacetyl chloride in 200 milliliters toluene was refluxed at about 110° C. for 20 hours. Upon cooling to -10° C., 2.7 grams pure product precipitated; m.p. 223° C. An additional 6.0 grams product was isolated by removal of the low boiling materials in vacuo. Total yield was 92%.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US04337081 |
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| Quelldatensatz | uspto-grants-1982_06 |
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| ORD ID | ord-36de979bf96c461c9ee5e39d26fdcd9c |
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| Quellennotiz | uspto-grants-1982_06 |
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