3-(3,4-Dihydroxyphenyl)Prop-2-Enoic Acid → Acetoacetic Acid

Beteiligte Stoffe

Reaktionsschritte

In accordance with the above flowchart, 3,4-dihydroxycinnamic acid (1) is reacted with acetic anhydride in pyridine for 18-30 hours and then extracted with organic solvents, giving 3,4-dihydroxycinnamic acid, diacetate (2) which is further converted to the 3,4-dihydroxycinnamic acid chloride (3) by treatment with thionyl chloride in dimethylformamide at -20° to -18° C. for 30-90 minutes.

Herkunft & Nachweise