Boron Trichloride → 4-Amino-2-bromophenol

HRID 1157156Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1157156
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([O:8]CC2C=CC=CC=2)=[C:4]([Br:16])[CH:3]=1.B(Cl)(Cl)Cl>ClCCl>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([Br:16])[CH:3]=1

Komponenten

4

Edukt 2

HCID 25135Boron TrichlorideHCID 220177374-Benzyloxy-3-bromophenylamine

Produkt 1

HCID 144402654-Amino-2-bromophenolAusbeute 56 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 4-amino-1-benzyloxy-2-bromobenzene in 2 mL of dichloromethane at −78 C was added boron trichloride (0.4 mL, 1 M in DCM) dropwise. The reaction was quenched with water at 0 C, concentrated and dried under vacuum to afford 4-amino-2-bromo-1-hydroxybenzene (17 mg, 56% two steps)

Aufarbeitung

  1. customThe reaction was quenched with water at 0 C
  2. concentrationconcentrated
  3. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-3ae0cd9993264b1a84990d5f8de9d37e
Quelldatensatz
uspto-grants-2010_10
Patentnummer
US07807672B2

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