Tributylamine → Clodronate

HRID 1157346

Reaktionsgleichung

Reaktionsgleichung von HRID 1157346
[Na+].[Na+].[Cl:3][C:4]([Cl:13])([P:9](=[O:12])([O-:11])[O-:10])[P:5](=[O:8])([OH:7])[OH:6].C(N(CCCC)CCCC)CCC>>[Cl:13][C:4]([Cl:3])([P:5](=[O:6])([OH:8])[OH:7])[P:9](=[O:10])([OH:11])[OH:12]

Komponenten

3

Edukt 2

HCID 7622TributylamineHCID 73554303Dichloromethylenediphosphonic acid

Produkt 1

HCID 25419Clodronate

Versuchsvorschrift

An aqueous solution of dichloromethylenediphosphonic acid disodium salt (1.0 g, 3.46 mmol) was loaded on a column of DOWEX 50WX8-100 ion-exchange resin and eluted with water. Tributylamine (1.65 mL, 6.92 mmol) was added and the mixture was shaken vigorously. The resulting solution was concentrated to dryness and coevaporated with anhydrous DMF three times. The residue was dried under vacuum overnight.

Aufarbeitung

  1. washeluted with water
  2. concentrationThe resulting solution was concentrated to dryness
  3. customThe residue was dried under vacuum overnight

Quellen und Nachweise

ORD-Eintrag
ord-eee9d7e1acb74bf79f8becde6b56a395
Quelldatensatz
uspto-grants-2010_10
Patentnummer
US07807653B2

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