(R)-3-(5-chloroindole-2-carbonylamino)-3,4-dihydrocarbostyril → (s)-3-(5-Chloroindole-2-carbonylamino)-1-methyl-3,4-dihydrocarbostyril

HRID 11586

Reaktionsgleichung

Reaktionsgleichung von HRID 11586
ClC1C=C2C(=CC=1)NC(C(N[C@@H]1CC3C(=CC=CC=3)NC1=O)=O)=C2.[Cl:25][C:26]1[CH:27]=[C:28]2[C:32](=[CH:33][CH:34]=1)[NH:31][C:30]([C:35]([NH:37][C@@H:38]1[CH2:47][C:46]3[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=3)[N:40]([CH3:48])[C:39]1=[O:49])=[O:36])=[CH:29]2.C(OC(N[C@@H]1CC2C(=CC=CC=2)NC1=O)=O)(C)(C)C>>[Cl:25][C:26]1[CH:27]=[C:28]2[C:32](=[CH:33][CH:34]=1)[NH:31][C:30]([C:35]([NH:37][C@H:38]1[CH2:47][C:46]3[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=3)[N:40]([CH3:48])[C:39]1=[O:49])=[O:36])=[CH:29]2

Komponenten

4

Edukt 3

HCID 9840862(R)-3-(5-chloroindole-2-carbonylamino)-3,4-dihydrocarbostyrilHCID 44357938(R)-3-(5-chloroindole-2-carbonylamino)-1-methyl-3,4-dihydrocarbostyrilHCID 69198597(R)-3-t-butyloxycarbonylamino-3,4-dihydrocarbostyril

Produkt 1

HCID 44357937(s)-3-(5-Chloroindole-2-carbonylamino)-1-methyl-3,4-dihydrocarbostyril

Versuchsvorschrift

The title compound was prepared from (S)-3-t-butyloxycarbonylamino-3,4-dihydrocarbostyril (prepared in Example 5) by the procedures described for the preparation of (R)-3-(5-chloroindole-2-carbonylamino)-1-methyl-3,4-dihydrocarbostyril (Example 14) from (R)-3-t-butyloxycarbonylamino-3,4-dihydrocarbostyril. HPLC/MS [M+H]+, 354.

Quellen und Nachweise

ORD-Eintrag
ord-f9013a076f6747788b58534bb7b45797
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07098235B2

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