Hydrochloric Acid → (S)-1-allyl-3-amino-3,4-dihydrocarbostyril hydrochloride

HRID 11587Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 11587
[CH2:1]([N:4]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:8][C@H:7]([NH:15]C(OC(C)(C)C)=O)[C:5]1=[O:6])[CH:2]=[CH2:3].[ClH:23]>O1CCOCC1>[ClH:23].[CH2:1]([N:4]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:8][C@H:7]([NH2:15])[C:5]1=[O:6])[CH:2]=[CH2:3]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 22868905(S)-1-allyl-3-t-butyloxycarbonylamino-3,4-dihydrocarbostyril

Produkt 1

HCID 69195858(S)-1-allyl-3-amino-3,4-dihydrocarbostyril hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

(S)-1-allyl-3-t-butyloxycarbonylamino-3,4-dihydrocarbostyril (9.7 mg) was dissolved in 4 M hydrogen chloride in 1,4-dioxane solution (2 mL) at room temperature, and a white precipitate soon formed. After 30 min the solvent was evaporated under vacuum, and the residue was twice taken up in toluene (5 mL) and evaporated to provide (S)-1-allyl-3-amino-3,4-dihydrocarbostyril hydrochloride (7.6 mg).

Aufarbeitung

  1. customa white precipitate soon formed
  2. customAfter 30 min the solvent was evaporated under vacuum
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-5adcca477c254be6a192106fe55a0014
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07098235B2

Notizen zur Reaktion

Wird geladen…