Hydrochloric Acid → HCID 22640117, Verbindung

HRID 1158708Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1158708
[C:1]1([C:7]2[CH:12]=[CH:11][N:10]=[C:9]([N:13]3[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]3)[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl>CO>[C:1]1([C:7]2[CH:12]=[CH:11][N:10]=[C:9]([N:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)[CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 68644576Tert-butyl 4-(4-phenylpyridin-2-yl)piperazine-1-carboxylate

Produkt 1

HCID 22640117HCID 22640117, VerbindungAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of tert-butyl 4-(4-phenylpyridin-2-yl)piperazine-1-carboxylate (390 mg, 1.15 mmol) and 2N methanol solution of hydrogen chloride (30 ml) was stirred at room temperature for 4 hours, and the solvent was distilled away under reduce pressure. To the residue was added 1N aqueous solution of sodium hydroxide (10 ml), extracted with chloroform (10 ml), and the extract was dried over anhydrous magnesium sulfate, and then the solvent was distilled away under reduce pressure to give the titled compound 275 mg (100%) as an oil product.

Aufarbeitung

  1. distillationthe solvent was distilled away
  2. additionTo the residue was added 1N aqueous solution of sodium hydroxide (10 ml)
  3. extractionextracted with chloroform (10 ml)
  4. dry with materialthe extract was dried over anhydrous magnesium sulfate
  5. distillationthe solvent was distilled away

Quellen und Nachweise

ORD-Eintrag
ord-8a228e572fb24625ac9e205e989c633d
Quelldatensatz
uspto-grants-2010_10
Patentnummer
US07812025B2

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