Potassium Carbonate → 5-Amino-1-methyl-1,6-dihydropyrazin-2(3H)-one

HRID 1158865Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1158865
Cl.[NH2:2][C:3]1[CH2:8][N:7]([CH3:9])[C:6](=[O:10])[CH2:5][N:4]=1.C(=O)([O-])[O-].[K+].[K+]>CO>[NH2:2][C:3]1[CH2:8][N:7]([CH3:9])[C:6](=[O:10])[CH2:5][N:4]=1

Komponenten

4

Edukt 2

HCID 11430Potassium CarbonateHCID 219413655-amino-1-methyl-3,6-dihydro-1H-pyrazin-2-one hydrochloride

Produkt 1

HCID 219413665-Amino-1-methyl-1,6-dihydropyrazin-2(3H)-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 5-amino-1-methyl-3,6-dihydro-1H-pyrazin-2-one hydrochloride (662 mg) in methanol (10 mL) was added 10% potassium carbonate aqueous solution at 0° F. and then stirred for 40 min at 0□. The mixture was concentrated under reduced pressure. The residue was triturated with chloroform (18 mL) and methanol (2 mL) at room temperature for 30 min. The precipitate was filtered off and dried in vacuo. The compound was obtained as a pale brown powder (515 mg, quantitative).

Aufarbeitung

  1. concentrationThe mixture was concentrated under reduced pressure
  2. customThe residue was triturated with chloroform (18 mL) and methanol (2 mL) at room temperature for 30 min
  3. filtrationThe precipitate was filtered off
  4. customdried in vacuo
  5. customThe compound was obtained as a pale brown powder (515 mg, quantitative)

Quellen und Nachweise

ORD-Eintrag
ord-30ab975d9433465aa82428a1b34e4dd5
Quelldatensatz
uspto-grants-2010_10
Patentnummer
US07812014B2

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