HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Methoxyethanol → 5-(4-Chloro-phenyl)-N-((R)-1-hydroxymethyl-pentyl)-6-(2-methoxy-ethoxy)-nicotinamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Methoxyethanol | HCID 8019 | — |
| Edukt | 4-Chlorophenylboronic acid | HCID 74299 | — |
| Edukt | Methyl 5-bromo-6-hydroxynicotinate | HCID 2764315 | — |
| Edukt | (R)-2-Aminohexan-1-ol | HCID 6994402 | — |
| Produkt | 5-(4-Chloro-phenyl)-N-((R)-1-hydroxymethyl-pentyl)-6-(2-methoxy-ethoxy)-nicotinamide | HCID 24856590 | — |
Reaktionsschritte
The title compound was synthesized in analogy to the procedure described for the preparation of Example 6, using 5-bromo-1,6-dihydro-6-oxo-3-pyridinecarboxylic acid methyl ester, 2-methoxy-ethanol (commercially available), 4-chlorophenyl-boronic acid (commercially available) and (R)-(−)-2-amino-1-hexanol (commercially available) as starting materials. MS (ISP): 407.4 (M+H+).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07812028B2 |
| Quelldatensatz | uspto-grants-2010_10 |
| ORD ID | ord-02cc65a1fc2f4a0c89112488725f2fa5 |
| Quellennotiz | uspto-grants-2010_10 |