3-Hydroxy-1,2-benzisoxazole → (3S,4R)-4-(Benzo[d]isoxazol-3-yloxy)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile

HRID 1159619Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1159619
[CH3:1][C:2]1([CH3:15])[O:11][C:10]2[C:5](=[CH:6][C:7]([C:12]#[N:13])=[CH:8][CH:9]=2)[C@@H:4]2[O:14][C@H:3]12.[O:16]1[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[C:18](=[O:25])[NH:17]1>>[O:16]1[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[C:18]([O:25][C@@H:4]2[C:5]3[C:10](=[CH:9][CH:8]=[C:7]([C:12]#[N:13])[CH:6]=3)[O:11][C:2]([CH3:1])([CH3:15])[C@H:3]2[OH:14])=[N:17]1

Komponenten

3

Edukt 2

HCID 2108303-Hydroxy-1,2-benzisoxazoleHCID 9837089(1aS,7bS)-2,2-Dimethyl-1a,7b-dihydro-2H-oxireno[2,3-c]chromene-6-carbonitrile

Produkt 1

HCID 68644303(3S,4R)-4-(Benzo[d]isoxazol-3-yloxy)-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile

Versuchsvorschrift

Following the procedure in Example 1, using (S,S)-2,2-dimethyl-1a,7b-dihydro-2H-1,3-dioxa-cyclopropa[a]naphthalene-6-carbonitrile and benzo[d]isoxazol-3-one as starting materials, the title compound was prepared as a white solid.

Quellen und Nachweise

ORD-Eintrag
ord-6ddcac7bc7f24b529d1b75e1623b2232
Quelldatensatz
uspto-grants-2010_10
Patentnummer
US07812183B2

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